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- Title
eIF4A1 Inhibitor Suppresses Hyperactive mTOR-Associated Tumors by Inducing Necroptosis and G2/M Arrest.
- Authors
Han, Luyang; Wu, Yuting; Liu, Fangming; Zhang, Hongbing
- Abstract
Aberrantly activated mechanistic target of rapamycin (mTOR) signaling pathway stimulates translation initiation/protein synthesis and eventually causes tumors. Targeting these processes thus holds potential for treating mTOR-associated diseases. We tested the potential of eFT226, a sequence-selective inhibitor of eIF4A-mediated translation, in the treatment of mTOR hyperactive cells caused by the deletion of tuberous sclerosis complex 1/2 (TSC1/2) or phosphatase and TENsin homology (PTEN). eFT226 preferentially inhibited the proliferation of Tsc2- and Pten-deficient cells by inducing necroptosis and G2/M phase arrest. In addition, eFT226 blocked the development of TSC2-deficient tumors. The translation initiation inhibitor is thus a promising regimen for the treatment of hyperactive mTOR-mediated tumors.
- Subjects
TUBEROUS sclerosis; PROTEIN synthesis; GENETIC translation; ARREST; TUMORS
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 13, p6932
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23136932