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- Title
Mass Spectrometry-Based Glycoproteomics and Prostate Cancer.
- Authors
Gabriele, Caterina; Prestagiacomo, Licia E.; Cuda, Giovanni; Gaspari, Marco; Peracaula, Rosa
- Abstract
Aberrant glycosylation has long been known to be associated with cancer, since it is involved in key mechanisms such as tumour onset, development and progression. This review will focus on protein glycosylation studies in cells, tissue, urine and serum in the context of prostate cancer. A dedicated section will cover the glycoforms of prostate specific antigen, the molecule that, despite some important limitations, is routinely tested for helping prostate cancer diagnosis. Our aim is to provide readers with an overview of mass spectrometry-based glycoproteomics of prostate cancer. From this perspective, the first part of this review will illustrate the main strategies for glycopeptide enrichment and mass spectrometric analysis. The molecular information obtained by glycoproteomic analysis performed by mass spectrometry has led to new insights into the mechanism linking aberrant glycosylation to cancer cell proliferation, migration and immunoescape.
- Subjects
PROSTATE-specific antigen; PROSTATE cancer; CANCER cell proliferation; CANCER diagnosis; GLYCOSYLATION; CELL migration inhibition
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 10, p5222
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22105222