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- Title
The Transcription Factor TCF1 in T Cell Differentiation and Aging.
- Authors
Kim, Chulwoo; Jin, Jun; Weyand, Cornelia M.; Goronzy, Jörg J.
- Abstract
The transcription factor T cell factor 1 (TCF1), a pioneer transcription factor as well as a downstream effector of WNT/β-catenin signaling, is indispensable for T cell development in the thymus. Recent studies have highlighted the additional critical role of TCF1 in peripheral T cell responses to acute and chronic infections as well as cancer. Here, we review the regulatory functions of TCF1 in the differentiation of T follicular helper cells, memory T cells and recently described stem-like exhausted T cells, where TCF1 promotes less differentiated stem-like cell states by controlling common gene-regulatory networks. These studies also provide insights into the mechanisms of defective T cell responses in older individuals. We discuss alterations in TCF1 expression and related regulatory networks with age and their consequences for T cell responses to infections and vaccination. The increasing understanding of the pathways regulating TCF1 expression and function in aged T cells holds the promise of enabling the design of therapeutic interventions aiming at improving T cell responses in older individuals.
- Subjects
T cell differentiation; CELLULAR aging; TRANSCRIPTION factors; T cells
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 18, p6497
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21186497