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- Title
Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells.
- Authors
Russi, Sabino; Verma, Henu Kumar; Laurino, Simona; Mazzone, Pellegrino; Storto, Giovanni; Nardelli, Anna; Zoppoli, Pietro; Calice, Giovanni; La Rocca, Francesco; Sgambato, Alessandro; Lucci, Valeria; Falco, Geppino; Ruggieri, Vitalba
- Abstract
Despite the significant recent advances in clinical practice, gastric cancer (GC) represents a leading cause of cancer-related deaths in the world. In fact, occurrence of chemo-resistance still remains a daunting hindrance to effectiveness of the current approach to GC therapy. There is accumulating evidence that a plethora of cellular and molecular factors is implicated in drug-induced phenotypical switching of GC cells. Among them, epithelial-mesenchymal transition (EMT), autophagy, drug detoxification, DNA damage response and drug target alterations, have been reported as major determinants. Intriguingly, resistant GC phenotype may be the result of GC cell-induced tumor microenvironment (TME) remodeling, which is currently emerging as a key player in promoting drug resistance and overcoming cytotoxic effects of drugs. In this review, we discuss the possible mechanisms of drug resistance and their involvement in determining current GC therapies failure.
- Subjects
STOMACH cancer; CANCER cells; PHARMACOLOGY; DRUG resistance; DNA damage; DRUG resistance in microorganisms
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 15, p3736
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20153736