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- Title
Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases.
- Authors
Francisqueti-Ferron, Fabiane Valentini; Ferron, Artur Junio Togneri; Garcia, Jéssica Leite; Silva, Carol Cristina Vágula de Almeida; Costa, Mariane Róvero; Gregolin, Cristina Schmitt; Moreto, Fernando; Ferreira, Ana Lúcia A.; Minatel, Igor Otávio; Correa, Camila Renata
- Abstract
The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement of Nrf2 on these conditions is complex and needs to be clarified. Here, a brief compilation of the Nrf2 enrollment in the pathophysiology of the most common age-related diseases and bring insights for future research on the Nrf2 pathway is described. This review shows a controversial response of this transcriptional factor on the presented diseases. This reinforces the necessity of more studies to investigate modulation strategies for Nrf2, making it a possible therapeutic target in the treatment of age-related disorders.
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 13, p3208
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20133208