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- Title
Fatal Primary Amebic Meningoencephalitis due to Naegleria fowleri: The First Imported Case in Korea.
- Authors
Kyung-Wook Hong; Jong Hwan Jeong; Jung-Hyun Byun; Sung-Hee Hong; Jung-Won Ju; In-Gyu Bae
- Abstract
Primary amebic meningoencephalitis (PAM) is a rare, but almost always fatal, central nervous system infection caused by Naegleria fowleri, which are thermophilic free-living amoeba. Here, we report the first case of PAM detected in South Korea, probably imported from Thailand. Despite antimicrobial treatment for N. fowleri infection with a combination of intravenous liposomal amphotericin B, fluconazole, azithromycin, and oral rifampin, the patient died 13 days after the onset of symptoms. Clinicians in South Korea treating severe meningoencephalitis, especially in individuals returning from tropical areas, are encouraged to include PAM in the differential diagnoses, given the accelerated global warming and increased overseas trips.
- Subjects
SOUTH Korea; THAILAND; NAEGLERIA fowleri; CENTRAL nervous system infections; MENINGOENCEPHALITIS; AMPHOTERICIN B; CANDIDEMIA
- Publication
Yonsei Medical Journal, 2023, Vol 64, Issue 10, p641
- ISSN
0513-5796
- Publication type
Case Study
- DOI
10.3349/ymj.2023.0189