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- Title
Convenient One-Pot Room Temperature Synthesis of 2-(trifluoromethyl)-1,2,3,4,7,8-hexahydroquinolin-5(6 H)-one derivatives via Catalyst-Free.
- Authors
Liang ‐ Ce, Rong; Tao, Shimin; Zha, Yunyun; Xia, Sheng; Gao, Yanian; Chen, Ming
- Abstract
This paper describes an efficient approach for the synthesis of 2-(trifluoromethyl)-1,2,3,4,7,8-hexahydroquinolin-5(6 H)-one derivatives via a one-pot four-component reaction of aromatic aldehyde, 5,5-dimethylcyclohexane-1,3-dione, 4,4,4-trifluoro-1-(thien-2-yl)butane-1,3-dione, and NH4OAc with excellent yields at room temperature. In this synthesis, the trifluoromethyl was efficiently introduced in hexahydroquinoline structure, and they may be valuable the drug candidates. This approach also offered several other advantages, such as catalyst-free, mild conditions, and simple experimental operation.
- Subjects
CHEMICAL synthesis; CHEMICAL derivatives; TRIFLUOROMETHYL compounds; CHEMICAL reactions; AROMATIC aldehydes
- Publication
Journal of Heterocyclic Chemistry, 2015, Vol 52, Issue 6, p1800
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.2267