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- Title
Synthesis and.
- Authors
Shen, Shengqiang; Sun, Xiaohong; Liu, Yuanfa; Chen, Bang; Jin, Ruyi; Ma, Haixia
- Abstract
A series of novel Mannich base derivatives (E1-E15) of 5-aryl-1,3,4-oxadiazole-2-thione with substituted pyrimidine were synthesized and characterized by elemental analysis, IR, 1H-NMR. The antifungal activities of these compounds were also originally studied. The results showed that most of the title compounds exhibited relatively good fungicidal activities. Especially compounds E8 and E13 showed better antifungal activity than comparison compound hymexazol. The relationship of structure and activity revealed that the presence of the methyl group at four and six positions of pyrimidine ring remarkably enhanced the antifungal activity of title compounds.
- Subjects
PYRIMIDINE synthesis; MANNICH bases; OXADIAZOLES; ANTIFUNGAL agents; CARBONYL compounds
- Publication
Journal of Heterocyclic Chemistry, 2015, Vol 52, Issue 5, p1296
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.2224