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- Title
Molecular mechanisms in successful peripheral regeneration.
- Authors
Makwana, Milan; Raivich, Gennadij
- Abstract
Peripheral nerve injury is normally followed by a robust regenerative response. Here we describe the early changes associated with injury from the initial rise in intracellular calcium and the subsequent activation of transcription factors and cytokines leading to an inflammatory reaction, and the expression of growth factors, cytokines, neuropeptides, and other secreted molecules involved in cell-to-cell communication promoting regeneration and neurite outgrowth. The aim of this review is to summarize the molecular mechanisms that play a part in executing successful regeneration.
- Subjects
PERIPHERAL nerve injuries; CELL adhesion molecules; CYTOKINES; CYTOSKELETON; MITOGENS; PROTEIN kinases; NERVOUS system regeneration; TRANSCRIPTION factors
- Publication
FEBS Journal, 2005, Vol 272, Issue 11, p2628
- ISSN
1742-464X
- Publication type
Article
- DOI
10.1111/j.1742-4658.2005.04699.x