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- Title
INFECTION IN PREGNANCY WITH EPILEPSIA.
- Authors
Tsivtsivadze, E. B.; Petrukhin, V. A.; Novikova, S. V.; Ryazantseva, E. V.; Vlasov, P. N.; Bocharova, I. I.
- Abstract
Epilepsy is the most common neurological disorder in women of reproductive age. The inflammatory process in the CNS leads to the induction of convulsive syndrome, which negatively affects the condition of the newborn. The aim of the study was to improve perinatal and obstetric outcomes in patients with epilepsy. Materials and methods: from 2014 to 2016, 129 pregnant women with epilepsy were under observation. PCR was used to diagnose viral infections, antibodies to neurospecific proteins S-100, GFAP, MBP and NGF were studied, and interferon status was determined. Group I - 59 pregnant women, who had a reduced level of neuroantibodies, negative PCR diagnosis and normal interferon status. Group II included 42 pregnant women with positive PCR diagnostics, a high level of antibodies to the NBP, a decrease in I N α serum <4 U / ml. In pregnant women of the II group interferon alpha-2b was used. A second examination was performed before delivery. Results: at the moment of delivery in Group II the level of neurosensitization decreased by 2.5 times, the virus DNA was not detected. Spontaneous delivery in group I - 83%, in group II 76.2%, in comparison group 82.2%. With an Apgar score 8 -9 85% of children were born. Hypoxia in labor occurred in 15% in the I group, 11.9% - in II. Signs of intrauterine invection in children from mothers of group I were revealed in 16.7%, from mothers of group II - in 4.8%. In the study of NSP in children of the I group, significant hyposensitization was found, in group II - within the limits of reference values. Conclusions: the inclusion of interferon alfa-2b in the complex of ongoing treatment prevented the development of severe forms of IUI and perinatal CNS damage in newborns.
- Subjects
SERBIA; CONFERENCES &; conventions; EPILEPSY in pregnancy; INFECTION; EVALUATION of medical care; PREGNANCY
- Publication
Journal of Perinatal Medicine, 2017, Vol 45, p234
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/jpm-2017-3002