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- Title
Crystal structure of XMRV protease differs from the structures of other retropepsins.
- Authors
Mi Li; DiMaio, Frank; Dongwen Zhou; Gustchina, Alla; Lubkowski, Jacek; Dauter, Zbigniew; Baker, David; Wlodawer, Alexander
- Abstract
Using energy and density guided Rosetta refinement to improve molecular replacement, we determined the crystal structure of the protease encoded by xenotropic murine leukemia virus-related virus (XMRV). Despite overall similarity of XMRV protease to other retropepsins, the topology of its dimer interface more closely resembles those of the monomeric, pepsin-like enzymes. Thus, XMRV protease may represent a distinct branch of the aspartic protease family.
- Subjects
MOLECULAR structure; PROTEOLYTIC enzymes; LEUKEMIA; PEPSIN; ENZYMES
- Publication
Nature Structural & Molecular Biology, 2011, Vol 18, Issue 2, p227
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.1964