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- Title
Structure of a purine-purine wobble base pair in the decoding center of the ribosome.
- Authors
Murphy IV, Frank V.; Ramakrishnan, V.
- Abstract
Here we report the crystal structures of I·C and I·A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I·A base pair is of an Ianti·Aanti conformation, as predicted by Crick. Additionally, the structures enable the observation of changes in the anticodon to allow purine-purine base pairing, the 'widest' base pair geometry allowed in the wobble position.
- Subjects
PURINES; RIBOSOME structure; MOLECULAR structure; MOLECULAR biology; PROTEOMICS; GENETICS
- Publication
Nature Structural & Molecular Biology, 2004, Vol 11, Issue 12, p1251
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb866