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- Title
Palladium-Catalyzed Intramolecular ipso-Friedel-Crafts Allylic Alkylation of Phenols via Arylative Activation of Allenes.
- Authors
Nemoto, Tetsuhiro; Nozaki, Tomoyuki; Yoshida, Mariko; Hamada, Yasumasa
- Abstract
A novel and efficient synthetic method for functionalized spiro[4.5]cyclohexadienones was developed based on the palladium-catalyzed sequential process: Heck insertion to an allene-intramolecular ipso-Friedel-Crafts allylic alkylation cascade. Using 5 mol% of palladium catalyst, a wide variety of spirocycles was obtained in good to excellent yields. The developed cascade process was also applicable to the synthesis of tetrahydronaphthalene derivatives.
- Subjects
PALLADIUM; ALLENE; ALLYLIC alkylation; ALKYLATION; SPIRO compounds; PALLADIUM catalysts
- Publication
Advanced Synthesis & Catalysis, 2013, Vol 355, Issue 13, p2693
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201300326