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- Title
The role of adjuvant chemotherapy in patients with H3K27 altered diffuse midline gliomas: a multicentric retrospective study.
- Authors
Di Nunno, Vincenzo; Lombardi, Giuseppe; Simonelli, Matteo; Minniti, Giuseppe; Mastronuzzi, Angela; Di Ruscio, Valentina; Corrà, Martina; Padovan, Marta; Maccari, Marta; Caccese, Mario; Simonetti, Giorgia; Berlendis, Arianna; Farinotti, Mariangela; Pollo, Bianca; Antonelli, Manila; Di Muzio, Antonio; Dipasquale, Angelo; Asioli, Sofia; De Biase, Dario; Tosoni, Alicia
- Abstract
Purpose: Adult Diffuse midline glioma (DMG) is a very rare disease. DMGs are currently treated with radiotherapy and chemotherapy even if only a few retrospective studies assessed the impact on overall survival (OS) of these approaches. Methods: We carried out an Italian multicentric retrospective study of adult patients with H3K27-altered DMG to assess the effective role of systemic therapy in the treatment landscape of this rare tumor type. Results: We evaluated 49 patients from 6 Institutions. The median age was 37.3 years (range 20.1–68.3). Most patients received biopsy as primary approach (n = 30, 61.2%) and radiation therapy after surgery (n = 39, 79.6%). 25 (51.0%) of patients received concurrent chemotherapy and 26 (53.1%) patients received adjuvant temozolomide. In univariate analysis, concurrent chemotherapy did not result in OS improvement while adjuvant temozolomide was associated with longer OS (21.2 vs. 9.0 months, HR 0.14, 0.05–0.41, p < 0.001). Multivariate analysis confirmed the role of adjuvant chemotherapy (HR 0.1, 95%CI: 0.03–0.34, p = 0.003). In patients who progressed after radiation and/or chemotherapy the administration of a second-line systemic treatment had a significantly favorable impact on survival (8.0 vs. 3.2 months, HR 0.2, 95%CI 0.1–0.65, p = 0.004). Conclusion: In our series, adjuvant treatment after radiotherapy can be useful in improving OS of patients with H3K27-altered DMG. When feasible another systemic treatment after treatment progression could be proposed.
- Subjects
ADJUVANT chemotherapy; GLIOMAS; RADIOTHERAPY; RETROSPECTIVE studies; UNIVARIATE analysis
- Publication
Journal of Neuro-Oncology, 2024, Vol 167, Issue 1, p145
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-024-04589-3