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- Title
Contrast-enhancement in supratentorial low-grade gliomas: a classic prognostic factor in the molecular age.
- Authors
Castet, Florian; Alanya, Enrique; Vidal, Noemi; Izquierdo, Cristina; Mesia, Carlos; Ducray, François; Gil-Gil, Miguel; Bruna, Jordi
- Abstract
Background: Contrast enhancement (CE) is found in 10–60% of low-grade gliomas. Its prognostic significance is controversial, and its correlation with IDH mutations and 1p/19q codeletion is elusive. The aim of this study is to investigate whether CE is associated with molecular characteristics of low-grade gliomas and uncover its prognostic value. Materials and methods: All confirmed histological cases of low-grade gliomas diagnosed at our institution between years 2000–2016 were reviewed (n = 102). Spinal and brainstem localization, only-biopsied tumours with ring-like enhancement and incomplete medical records were excluded. Results: Mean age was 42 years (± 13.9 years), and 63.6% were male. The median follow-up time was 79.8 months. CE was present on 25% of preoperative MRI, and 25% of patients were considered high-risk according to Pignatti score. Most were astrocytomas (67%) and 87.2% were surgically removed. IDH mutation was found in 64.6% of tumour samples, and 18.8% had a 1p/19q codeletion. No subgroup differences were observed according to CE except for presurgical performance status and postoperative chemotherapy. IDH status and 1p/19q codeletion were evenly distributed. On univariate analysis, age, size > 6 cm, CE, extent of resection, Pignatti score, IDH mutation and 1p/19q codeletion were significantly associated to OS. On multivariate analysis, only CE and IDH status were independently associated to OS. CE remained a significant prognostic factor in IDH-mutant non-codeleted tumours when analysed by tumour subtype. Conclusion: CE in low-grade gliomas provides prognostic information in IDH-mutant non-codeleted tumours, although its meaning remains uncertain in IDH-wildtype gliomas.
- Subjects
GLIOMAS; OLIGODENDROGLIOMAS; UNIVARIATE analysis; MULTIVARIATE analysis; TUMORS; MEDICAL records
- Publication
Journal of Neuro-Oncology, 2019, Vol 143, Issue 3, p515
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-019-03183-2