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- Title
Targeted PARACEST nanoparticle contrast agent for the detection of fibrin.
- Authors
Winter, Patrick M.; Cai, Kejia; Chen, Junjie; Adair, Christopher R.; Kiefer, Garry E.; Athey, Phillip S.; Gaffney, Patrick J.; Buff, Carolyn E.; Robertson, J. David; Caruthers, Shelton D.; Wickline, Samuel A.; Lanza, Gregory M.
- Abstract
A lipid-encapsulated perfluorocarbon nanoparticle molecular imaging contrast agent that utilizes a paramagnetic chemical exchange saturation transfer (PARACEST) chelate is presented. PARACEST agents are ideally suited for molecular imaging applications because one can switch the contrast on and off at will simply by adjusting the pulse sequence parameters. This obviates the need for pre- and postinjection images to define contrast agent binding. Spectroscopy (4.7T) of PARACEST nanoparticles revealed a bound water peak at 52 ppm, in agreement with results from the water-soluble chelate. Imaging of control nanoparticles showed no appreciable contrast, while PARACEST nanoparticles produced >10% signal enhancement. PARACEST nanoparticles were targeted to clots via antifibrin antibodies and produced a contrast-to-noise ratio (CNR) of 10 at the clot surface. Magn Reson Med, 2006. © 2006 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2006, Vol 56, Issue 6, p1384
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.21093