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- Title
Appearance of focal cortical dysplasia on serial MRI after maturation of myelination.
- Authors
Fumiaki Yoshida; Takato Morioka; Kimiaki Hashiguchi; Yasushi Miyagi; Shinji Nagata; Yui Yamaguchi; Masaharu Ohfu; Tomio Sasaki
- Abstract
Abstract Case report  It is well known that magnetic resonance imaging (MRI) findings of focal cortical dysplasia (FCD) can change with maturation of myelination. In this paper, we report a patient with intractable epilepsy and negative MRI at the age of 2.5 years, after completion of myelination. Follow-up MRI at the age of 6 years revealed typical FCD findings in the right frontal lobe. During these 3.5 years, electroencephalogram (EEG) consistently depicted an area of irritation in accordance with de novo MRI findings. Intraoperative electrocorticogram showed frequent paroxysmal activity in the right frontal lobe; excision of the epileptogenic cortex resulted in a reduction in seizures. Conclusion  It is possible that FCD becomes apparent on MRI even after maturation of myelination; thus, repeated MRI is recommended while EEG continues to demonstrate focal findings.
- Subjects
ELECTROENCEPHALOGRAPHY; DIAGNOSTIC imaging; MAGNETIC resonance imaging; DEVELOPMENTAL disabilities
- Publication
Child's Nervous System, 2008, Vol 24, Issue 2, p269
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-007-0447-x