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- Title
Real-World Outcomes of Combination Chemotherapy with Trabectedin plus Pegylated Liposomal Doxorubicin in Patients with Recurrent Ovarian Cancer: A Single-Center Experience.
- Authors
Moriceau, Guillaume; Rivoirard, Romain; Méry, Benoîte; Vallard, alexis; Pacaut, Cécile; Trone, Jane-Chloé; Espenel, Sophie; Bosacki, Claire; Jacquin, Jean-Philippe; Magné, Nicolas
- Abstract
Background: Trabectedin plus pegylated liposomal doxorubicin (PLD) proved efficacious as second-line treatment for patients with recurrent ovarian cancer (ROC). Methods: We report a single-center retrospective analysis of the efficacy and tolerance of trabectedin 1.1 mg/m 2 every 3 weeks in a cohort of real-life ROC patients. Results: From February 2012 to January 2014, 17 patients were treated with trabectedin alone or combined with PLD. Median age was 61 years (range: 48-78). Performance status was 0-1 in 16 patients (94%). Disease response rate was 53% and disease control rate was 76%. At the end of the follow-up, 8 patients (47%) were alive. Median overall survival was 17.6 months (95% CI 13.6 to not reached). Median progression-free survival was 6.7 months (95% CI 5.4-10.0). The most frequent grade 3-4 toxicities were neutropenia (n = 4, 24%) and nausea/vomiting (n = 4, 24%). Conclusion: Trabectedin combined with PLD seems efficient in and well tolerated by real-life ROC patients.
- Subjects
COMBINATION drug therapy; TRABECTEDIN; CANCER chemotherapy; OVARIAN cancer; NEUTROPENIA; NAUSEA; PATIENTS
- Publication
Chemotherapy (0009-3157), 2016, Vol 61, Issue 3, p122
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000441378