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- Title
Lavender Oil Inhibits Immediate-type Allergic Reaction in Mice and Rats.
- Authors
KIM, HYUNG-MIN; CHO, SEONG-HOON
- Abstract
We studied the effects of lavender oil on mast cell-mediated immediate-type allergic reactions in mice and rats. Lavender oil ( 1:500, 1:100, 1:10, 1:1, 1:0) inhibited concentration-dependently mast cell-dependent ear swelling response induced by compound 48/80 in mice by both topical and intradermal application. Lavender oil ( 1:500, 1:100, 1:10, 1:1, 1:0) inhibited concentration-dependently passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) IgE in rats by both topical and intradermal application. Lavender oil ( 1:500, 1: 100, 1: 10, 1:1, 1:0) also inhibited concentration-dependently the histamine release from the peritoneal mast cells by compound 48/80 or anti-DNP IgE. Moreover, lavender oil ( 1:1000, 1:100, 1:10, 1:0) had a significant inhibitory effect on anti-DNP IgE-induced tumour necrosis factor-α secretion from peritoneal mast cells. These results indicate that lavender oil inhibits immediate-type allergic reactions by inhibition of mast cell degranulation in-vivo and in-vitro.
- Publication
Journal of Pharmacy & Pharmacology, 1999, Vol 51, Issue 2, p221
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1211/0022357991772178