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- Title
Efficient synthesis of both diastereomers of β,γ-diamino acids from phenylalanine and tryptophan.
- Authors
Auberger, Nicolas; Stanovych, Andrii; Thétiot-Laurent, Sophie; Guillot, Régis; Kouklovsky, Cyrille; Cote des Combes, Sylvain; Pacaud, Christophe; Devillers, Ingrid; Alezra, Valérie
- Abstract
We synthesized in a few steps both diastereomers of orthogonally protected β,γ-diamino acids starting from l-phenylalanine or l-tryptophan. These final compounds are interesting building blocks for peptide synthesis and foldamer chemistry. The key step is a Blaise reaction performed under ultrasound conditions.
- Subjects
DIASTEREOISOMERS synthesis; AMINO acids; PHENYLALANINE; TRYPTOPHAN; PEPTIDE synthesis
- Publication
Amino Acids, 2016, Vol 48, Issue 9, p2237
- ISSN
0939-4451
- Publication type
Article
- DOI
10.1007/s00726-016-2262-8