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- Title
Differentiation of Blood Islands in Chick Blastoderms in Association with Morris Hepatoma Grafts and its Relationship to Specific Chromosomal Changes in the Hepatomas.
- Authors
Sherbet, G.V.; Lakshmi, M.S.
- Abstract
Six Morris hepatomas were found to support differentiation of blood islands when implanted into 16-18- hour-old chick embryo blastoderms cultured in vitro. This ability was found to be associated largely with an extra chromosome in group 4-10 of the hepatoma genome. The Morris hepatomas extra chromosome occurred in 4 out of the 6 tumours studied. A fifth hepatoma produced blood islands condensation response equivalent to that associated with 1 extra chromosome in group 4-10 although its karyotype was apparently normal. The blood island-inducing ability was also partly associated with the addition of a No. 13 chromosome. Presence of 1 or more satellites on the No. 12 chromosomes suppressed this activity in 2 hepatomas. This correlation between 2 features, viz. specific chromosome additions and blood island-inducing ability, which are associated with neoplastic state of hepatic tissue, might be a result of linkage of genes responsible for the neoplastic behaviour and those responsible for the differentiation of blood islands, on a chromosome of group 4-10. Copyright © 1971 S. Karger AG, Basel
- Publication
Oncology, 1971, Vol 25, Issue 6, p558
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000224606