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- Title
Making digit patterns in the vertebrate limb.
- Authors
Tickle, Cheryll
- Abstract
The vertebrate limb has been a premier model for studying pattern formation — a striking digit pattern is formed in human hands, with a thumb forming at one edge and a little finger at the other. Classic embryological studies in different model organisms combined with new sophisticated techniques that integrate gene-expression patterns and cell behaviour have begun to shed light on the mechanisms that control digit patterning, and stimulate re-evaluation of the current models.
- Subjects
EMBRYOLOGY; PATTERN formation (Biology); DEVELOPMENTAL biology; GENE expression; GENETIC regulation; VERTEBRATES
- Publication
Nature Reviews Molecular Cell Biology, 2006, Vol 7, Issue 1, p45
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1830