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- Title
Opinion: Transactivation joins multiple tracks to the ERK/MAPK cascade.
- Authors
Wetzker, Reinhard; Böhmer, Frank-D.
- Abstract
Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway. A 'transactivation' mechanism, which links these events in one signalling chain, inspired many researchers, but inevitably raised new questions. A 'multi-track' model for GPCR signalling to the ERK/MAPK pathway might resolve some of the puzzles in the transactivation field.
- Subjects
G proteins; PROTEIN-tyrosine kinases; PROTEIN kinases; MEMBRANE proteins; PROTEINS
- Publication
Nature Reviews Molecular Cell Biology, 2003, Vol 4, Issue 8, p651
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1173