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- Title
Effect of Ascending Doses of Pentoxifylline Administration on Biochemical and Hematological Parameters in Goats.
- Authors
COŞKUN, Devran; ÇETİN, Gül; ÇORUM, Orhan
- Abstract
Pentoxifylline (PTX) is a non-selective phosphodiesterase inhibitor drug used in human and veterinary medicine to promote microcirculation. Although PTX has been used in experimental studies in goats, there is no information about its safety. The aim of this study is to determine the effect of PTX on hematological and biochemical parameters following intravenous (IV) administration of 10, 20 and 40 mg/kg doses to Hair goats. In the study were used clinically healthy 9 goats. PTX was administered IV to goats at doses of 10, 20 and 40 mg/kg. Blood samples were taken before drug administration (control, 0 hour) and 12 hours after administration, and hematological and biochemical parameters were evaluated. No local or systemic adverse effects were observed in goats after the application of PTX at different doses. After administration of PTX at 20 and 40 mg/kg doses, white blood cell (WBC) level increased, while hemoglobin (HGB) level decreased at 10 mg/kg dose (p<0.05). When compared with the 10 mg/kg dose group, WBC, red blood cell (except 40 mg/kg), HGB and hematocrit values were found to be increased in the 20 and 40 mg/kg dose groups (p<0.05). While the administration of PTX at different doses caused a general decrease in biochemical parameters (p<0.05), no change was observed in troponin I level. In conclusion, it can be stated that the administration of PTX in goats at doses of 10, 20 and 40 mg/kg caused significant changes in hematological and biochemical parameters and caution should be exercised as these temporary changes in single-dose administrations may pose a risk in repeated administrations.
- Subjects
PENTOXIFYLLINE; GOATS; PHOSPHODIESTERASE inhibitors; VETERINARY medicine; HEMOGLOBINS
- Publication
Kocatepe Veterinary Journal / Kocatepe Veteriner Dergisi, 2022, Vol 15, Issue 1, p63
- ISSN
1308-1594
- Publication type
Article
- DOI
10.30607/kvj.1055336