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- Title
Colorectal liver metastasis: molecular mechanism and interventional therapy.
- Authors
Zhou, Hui; Liu, Zhongtao; Wang, Yongxiang; Wen, Xiaoyong; Amador, Eric H.; Yuan, Liqin; Ran, Xin; Xiong, Li; Ran, Yuping; Chen, Wei; Wen, Yu
- Abstract
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.
- Publication
Signal Transduction & Targeted Therapy, 2022, Vol 7, Issue 1, p1
- ISSN
2095-9907
- Publication type
Article
- DOI
10.1038/s41392-022-00922-2