We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Improvement of a Device for Measurement of Femoral Neck Bone Strength in Osteopenia.
- Authors
Yu Kuwahara; Nobuo Izumo; Jun Sakurai; Kazuto Honma; Masaya Miyazaki; Megumi Furukawa; Makoto Nakano; Kohsuke Hayamizu; Yasuo Watanabe
- Abstract
The number of patients suffering from osteoporosis increases year by year. Osteoporosis is characterized by decreased bone strength and increases the risk of fracture. The femoral neck is the most possible part of the fracture. In this study, bone strength, particularly the femoral neck bone, of ovariectomized osteopenia (OVX) model mouse was measured using a newly improved stage device for femoral neck fracture. Female ICR mice were divided into the Sham and OVX groups. Eight weeks after surgery, right and left femurs were taken out. The right femur neck was set on an improved bone strength measurement device and the maximum breaking load (NT) was measured. Moreover, the left femur was measured for bone mineral density (BMD) using a CT. All results were regression analyzed with Stat View analysis software and their correlation was analyzed. As for the right femur, N value of the OVX group showed a significant decrease compared to that of the Sham group. As for the left femur, value of cancellous BMD of OVX group was also lower. Therefore, we examined the correlation between the BMD and bone strength of the Sham and OVX, respectively, and obtained a significant positive correlation. Moreover, when the correlation with stiffness and bone strength was also investigated as a parameter index of bone quality, significant positive correlation was found. The present study indicates that the novel strength measurement equipment of the femoral neck is useful for an evaluation of osteopenic model animals, for instance of OVX model mice.
- Subjects
FEMUR neck; OSTEOPENIA; OVARIECTOMY; BODY mass index; FEMUR
- Publication
Pharmacometrics / Ōyō Yakuri (0300-8533), 2019, Vol 96, Issue 3/4, p63
- ISSN
0300-8533
- Publication type
Article