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- Title
Glycosylation-directed quality control of protein folding.
- Authors
Xu, Chengchao; Ng, Davis T. W.
- Abstract
Membrane-bound and soluble proteins of the secretory pathway are commonly glycosylated in the endoplasmic reticulum. These adducts have many biological functions, including, notably, their contribution to the maturation of glycoproteins. N-linked glycans are of oligomeric structure, forming configurations that provide blueprints to precisely instruct the folding of protein substrates and the quality control systems that scrutinize it. O-linked mannoses are simpler in structure and were recently found to have distinct functions in protein quality control that do not require the complex structure of N-linked glycans. Together, recent studies reveal the breadth and sophistication of the roles of these glycan-directed modifications in protein biogenesis.
- Subjects
GLYCOSYLATION; QUALITY control; PROTEIN folding; ENDOPLASMIC reticulum; VESICULAR stomatitis; GLYCOPROTEINS
- Publication
Nature Reviews Molecular Cell Biology, 2015, Vol 16, Issue 12, p742
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm4073