The article highlights the research by Jim Norman and Colleagues on RAB25. It reports that the RAB25 directly interacts with and localizes alpha5beta1 integrin at the pseudopodial tips of migrating cells, thereby contributing to metastatic progression. Jim Norman and colleagues showed that GTP-bound RAB25 specifically interacted with beta1 subunit cytoplasmic tail of alpha5beta1 in human ovarian A2780 cancer cells.