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- Title
Cloning and characterization of GITR ligand.
- Authors
Kim, J. D.; Choi, B. K.; Bae, J. S.; Lee, U. H.; Han, I. S.; Lee, H. W.; Youn, B. S.; Vinay, D. S.; Kwon, B. S.
- Abstract
The gene encoding the natural ligand of murine glucocorticoid-induced tumor necrosis factor receptor (GITR) was cloned and characterized. The putative GITR ligand (GITRL) is composed of 173 amino acids with features resembling those of type II membrane proteins and is 51% identical to the human activation-inducible TNF receptor (AITR) ligand, TL6. Expression of the GITRL is restricted to immature and mature splenic dendritic cells. GITRL binds GITR expressed on HEK 293 cells and triggers NF-?B activation. Functional studies reveal that soluble CD8-GITRL prevents CD4+CD25+ regulatory T-cell-mediated suppressive activities.Genes and Immunity (2003) 4, 564-569. doi:10.1038/sj.gene.6364026
- Subjects
GENETIC engineering; TUMOR necrosis factors; LIGANDS (Biochemistry); CLONING; MOLECULAR genetics; GENE expression; GENETICS; IMMUNOLOGY
- Publication
Genes & Immunity, 2003, Vol 4, Issue 8, p564
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364026