We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
IMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN ORAL SQUAMOUS CELL CARCINOMA, ORAL EPITHELIAL PRECURSOR LESIONS, AND NORMAL ORAL MUCOSA.
- Authors
Khan, Abbas Saleem; Ahmed, Sajjad; Iqbal, Fatima; Saboor, Abdus; Nisar, Muhammad; Nausheen, Tehmina; Sheikh, Ahmareen; Haq, Mohsina; Ahmed, Tariq; Rehman, Bashir
- Abstract
Objective: To assess the immunohistochemical expression of p53 in tissue samples of oral squamous cell carcinoma (OSCC), oral epithelial precursor lesions, and normal oral mucosa. Material & Methods: A comparative cross-sectional study was jointly conducted at the Departments of Pathology and Oral and Maxillofacial Surgery of various medical and dental institutes of the country from April 2016 to March 2017. A total of 180 subjects were included in the study. Oral tissue specimens were collected for laboratory investigations after obtaining written consent from all subjects. p53 was assessed using immunohistochemistry in tissue samples of 60 cases of OSCC, 60 cases of epithelial precursor lesions, and normal oral mucosal samples of 60 healthy individuals. Data were recorded, evaluated, and analyzed by SPSS-20. Results: p53 protein expression was noted in 85% OSCC and 73% oral epithelial precursor lesions. Among healthy individuals, one subject showed p53 immunoreactivity in the normal oral mucosa. Conclusion: Raised p53 overexpression in OSCC and oral precursor lesions, compared to normal oral mucosa make it a probable candidate for a potential predictive biomarker in oral premalignancy and malignancy.
- Subjects
ORAL mucosa; SQUAMOUS cell carcinoma; P53 protein; TUMOR suppressor proteins; MAXILLOFACIAL surgery
- Publication
Journal of Medical Sciences (1997-3438), 2021, Vol 29, Issue 4, p255
- ISSN
1997-3438
- Publication type
Article
- DOI
10.52764/jms.21.29.4.9