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- Title
Oestrogen receptors revisited: long-term follow up of over five thousand breast cancer patients.
- Authors
Hähnel, Roland; Spilsbury, Katrina
- Abstract
The oestrogen receptor status of a breast tumour predicts the response to hormonal treatment and is an important prognostic marker; women with oestrogen receptor positive tumours having a better short-term survival outcome.Kaplan−Meier estimates and Cox proportional hazard model were used to estimate the association between oestrogen receptor levels and long-term breast cancer-specific survival outcomes in 5735 women diagnosed with breast carcinoma from 1970 to 1997 in Western Australia. Further analysis was performed on a subset of women for whom biochemical and tumour characteristics were also available.Five-year breast cancer-specific survival estimates for women with oestrogen receptor positive tumours was 0.85 (95% CI 0.84−86) compared to 0.72 (95% CI 0.70−74) for women with oestrogen receptor negative tumours. The relative survival advantage of an oestrogen positive tumour over oestrogen negative tumours disappeared by the fourth year (0.8, 95% CI 0.6−1.0). Conditional upon surviving 5 years, long-term breast cancer-specific survival was better for women with oestrogen receptor and progesterone receptor negative tumours compared to other women (log rank test P-value<0.05).Despite an earlier survival advantage for women diagnosed with oestrogen receptor positive tumours, after 5 years of survival, women with oestrogen receptor negative and progesterone receptor negative tumours had better long-term survival outcomes from breast cancer compared to other women.
- Subjects
ESTROGEN receptors; CANCER hormone therapy; BREAST cancer; CANCER treatment; TUMORS; SURGERY; MEDICINE
- Publication
ANZ Journal of Surgery, 2004, Vol 74, Issue 11, p957
- ISSN
1445-1433
- Publication type
Article
- DOI
10.1111/j.1445-1433.2004.03215.x