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- Title
Identification of active phytoconsituent in Morinda citrifolia for anti-cancer activity through docking studies.
- Authors
Srinivasahan, Vennila; Durairaj, Brindha
- Abstract
Morinda citrifolia commonly known as NONI has been traditionally used for the treatment of cancer and wide range of ailments. Identification of novel drug targets is essential for improvising the drug efficacy of Morinda citrifolia. Hence, the ability to predict the drug target by an insilico method is an initiation towards the drug discovery pipeline. Phytoconstituents of Morinda citrifolia were identified and prepared for docking using LigPrep. LigPrep is a utility of Schrodinger software that generates 3D structures from 2D representation. All docking calculations were performed using the "Extra precision" (XP) mode of Glide program. Aurora kinase, Estrogen receptor-a, fibroblast growth factor and C-kit are the proteins targeted with different phytocontituents like Rutin, Scopoletin, Monotropin and Methyl 3-(2, 4-dihydroxy-5-methoxyphenyl) propionate, c-kit is the main target of Rutin and the Glide energy (-64.904 kJ/ mol) was higher in the case of Rutin among the other compounds. This study concludes that natural products with interesting biological properties and structural diversity may serve as valuable lead drug candidates for the treatment of human diseases including cancer of different types in close proximity to future.
- Subjects
MORINDA citrifolia; MORINDA; CANCER treatment; SCOPOLETIN; DRUG efficacy
- Publication
International Journal of Pharma Research, 2015, Vol 6, Issue 1, p5
- ISSN
0975-3532
- Publication type
Article