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- Title
肝细胞癌中细胞因子信号传导抑制因子1与调节性 T淋巴细胞/ 辅助性T 淋巴细胞17 平衡的关系.
- Authors
宋 瑞; 李 静; 杨红菊; 李敏癑; 游 晶
- Abstract
The regulatory Tcells (Treg) and helper Tcells 17 (Th17) play an important role in regulation of the tumor microenvironment in hepatocellular carcinoma (HCC) because Treg/Thl 7 imbalance was associated with HCC cell invasion and progression. Moreover, the suppressor of cytokine signaling 1 ( SOCSl), a negative regulator of the Janus kinase ( JAK )/ signal transducers and activators of transcription (STAT) pathway, regulates Treg and Th 17 proliferation and differentiation. This review summarized and discussed the recent advancement and progress in control of the Treg/Th17 balance in HCC and the immunity - related mechanisms in HCC development and progression, i. e., the SOCSl structure and functions, SOCSl role in regulation of Treg/Thl 7 balance in HCC, and future research direction of the field .
- Publication
Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2022, Vol 38, Issue 11, p2627
- ISSN
1001-5256
- Publication type
Article
- DOI
10.3969/j.issn.1001-5256.2022.11.038