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- Title
Mapping the Haem-A-QoL to the EQ-5D-5L in patients with hemophilia.
- Authors
Xu, Richard Huan; Dong, Dong; Luo, Nan; Wong, Eliza Lai-Yi; Yang, Renchi; Liu, Junshuai; Yuan, Huiqin; Zhang, Shuyang
- Abstract
Objective: This study's objective was to develop an algorithm that mapping the Haem-A-QoL scores to EQ-5D-5L utility scores in patients with hemophilia in China. Methods: A national sample of 862 patients with hemophilia completed both the EQ-5D-5L and Haem-A-QoL instruments. Eight regression models were selected to develop the mapping algorithm, they were: the ordinary least squares, general linear regression, Tobit regression, censored least absolute deviation, mixture beta regression, adjusted limited dependent variable mixture, the two-part, and robust MM-estimator model. Root mean squared error (RMSE), mean absolute error (MAE), and R-square (R2) calculated using the tenfold cross-validation and random sample validation methods were used to assess the predictive ability of the models. Results: Based on RMSE, MAE, and R2, the mixture beta regression model with selected Haem-A-QoL subscale scores as the predicted variables showed the best performance. Conclusions: Our mapping algorithm bolsters the calculation of QALYs while conducting an economic evaluation of hemophilia-related interventions when only Haem-A-QoL data are available. The external validity of the algorithm should be further assessed in the other populations.
- Publication
Quality of Life Research, 2022, Vol 31, Issue 5, p1533
- ISSN
0962-9343
- Publication type
Article
- DOI
10.1007/s11136-021-03051-5