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- Title
The combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C.
- Authors
Vieira, Diego Alves; da Cunha, Luciana Rodrigues; da Silva, Cliviany Borges; Almeida, Maria Thereza Bastos; Gomes, Adriana Dias; de Faria, César Lúcio Lopes; Teixeira, Rosângela; Neves, Fernando Silva; Rocha, Gifone Aguiar; de Melo, Fabrício Freire; de Magalhães Queiroz, Dulciene Maria; Silva, Luciana Diniz; de Faria, César Lúcio Lopes Jr
- Abstract
<bold>Purpose: </bold>Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, - 819C/T, and - 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demographic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients.<bold>Methods: </bold>132 consecutive CHC patients and 98 controls underwent psychiatric evaluation by using the Mini International Neuropsychiatric Interview. HRQOL was assessed by a generic questionnaire, the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and by the specific Liver Disease Quality of Life Questionnaire (LDQOL). IL6 and IL10 polymorphisms were evaluated by Taqman SNP genotyping assay. Multivariate analysis was used to evaluate the associations.<bold>Results: </bold>Major depressive disorder was associated with lower SF-36 and LDQOL scores in seven and ten domains, respectively. Diabetes and hypertension were also associated with reduced HRQOL. CHC patients carrying the combination of IL10 ATA haplotype/IL6-GG genotype had lower scores in the SF-36-physical functioning domain, and reduced scores in the LDQOL effects of liver disease on activities of daily living, quality of social interaction, and sexual function domains than the non-carriers of the combined haplotype/genotype.<bold>Conclusion: </bold>This is the first study to demonstrate that combined IL6 high-producer GG genotype and IL10 low-producer ATA haplotype is associated with poorer HRQOL in CHC patients.
- Subjects
CHRONIC hepatitis C; INTERLEUKIN-10; QUALITY of life; GENOTYPES; MENTAL depression
- Publication
Quality of Life Research, 2019, Vol 28, Issue 6, p1531
- ISSN
0962-9343
- Publication type
journal article
- DOI
10.1007/s11136-019-02129-5