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- Title
Low Levels of Neutralizing Antibodies After Natural Infection With Severe Acute Respiratory Syndrome Coronavirus 2 in a Community-Based Serological Study.
- Authors
McDade, Thomas W; Sancilio, Amelia; D'Aquila, Richard; Mustanski, Brian; Vaught, Lauren A; Reiser, Nina L; Velez, Matthew E; Hsieh, Ryan R; Ryan, Daniel T; Saber, Rana; McNally, Elizabeth M; Demonbreun, Alexis R
- Abstract
Background Confidence in natural immunity after infection with severe acute respiratory syndrome coronavirus 2 is one reason for vaccine hesitancy. Methods We measured antibody-mediated neutralization of spike protein-ACE2 receptor binding in a large community-based sample of seropositive individuals who differed in severity of infection (N = 790). Results A total of 39.8% of infections were asymptomatic, 46.5% were symptomatic with no clinical care, 13.8% were symptomatic with clinical care, and 3.7% required hospitalization. Moderate/high neutralizing activity was present after 41.3% of clinically managed infections, in comparison with 7.9% of symptomatic and 1.9% of asymptomatic infections. Conclusions Prior coronavirus disease 2019 infection does not guarantee a high level of antibody-mediated protection against reinfection in the general population.
- Subjects
COVID-19
- Publication
Open Forum Infectious Diseases, 2022, Vol 9, Issue 3, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofac055