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- Title
New Insights of Turmeric Extract-Loaded PLGA Nanoparticles: Development, Characterization and In Vitro Evaluation of Antioxidant Activity.
- Authors
Gonzales, Camila Maria; Dalmolin, Luciana Facco; da Silva, Kátia Aparecida; Slade, Natália Bueno Leite; Lopez, Renata Fonseca Vianna; Moreto, Jeferson Aparecido; Schwarz, Kélin
- Abstract
Here, we presented new insights of the development of poly(lactic-co-glycolic acid) nanoparticles containing turmeric compounds (turmeric-PLGA-NPs) using emulsion-solvent evaporation method. The nanoparticulate system was characterized by size, zeta potential, morphology, release profile, partition parameter, stability and encapsulation efficiency (%EE). Antioxidant activity studies were also evaluated. The Korsmeyer-Peppas model (Mt/M∞ vs. t) was used to determine the release mechanisms of the studied system. Our results demonstrated the emulsion-solvent evaporation method was shown advantageous for producing turmeric-PLGA-NPs in the range of 145 nm with high homogeneity in size distribution, zeta potential of −21.8 mV and %EE about 72%. Nanoparticles were stable over a period of one month. In vitro study showed a release of curcumin governed by diffusion and relaxation of the polymeric matrix. The partition parameter of the extract in relation to blank-PLGA-NPs was 0.111 ± 0.008 M−1, indicating a low affinity of curcumin for the polymer matrix. Antioxidant ability of the turmeric-PLGA-NPs in scavenging the radical 2,2-azinobis (3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS) was inferior to free turmeric extract and showed a concentration and time-dependent profile. The study concluded that PLGA nanoparticles are potential carriers for turmeric extract delivery.
- Subjects
TURMERIC; ANTIOXIDANTS; NANOPARTICLES; ZETA potential; CURCUMIN; POLYMERS
- Publication
Plant Foods for Human Nutrition, 2021, Vol 76, Issue 4, p507
- ISSN
0921-9668
- Publication type
Article
- DOI
10.1007/s11130-021-00929-0