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- Title
Post-prandial glucose excursions following four methods of bolus insulin administration in subjects with Type 1 diabetes.
- Authors
Chase, H. P; Saib, S. Z; MacKenzie, T; Hansen, M. M; Garg, S. K
- Abstract
Abstract Aims To determine if one method of short-acting insulin bolus administration is superior to other methods in managing a meal high in carbohydrates, calories and fat. Methods Nine subjects receiving continuous subcutaneous insulin infusion using insulin lispro (Humalog®) agreed to consume the same meal high in carbohydrates, calories and fat on four occasions 1 week apart. They received the same dose of bolus insulin on each of the four occasions randomly assigned and beginning 10 min prior to the meal as either a single bolus, two separate boluses of one-half the same total dose (the second after 90 min), the entire bolus given as a square-wave (over 2 h) or a dual-wave (70% as a bolus and 30% as a square-wave over 2 h). Blood glucose levels were measured at –60 and –30 min and at zero time, and then every half-hour for 6 h using the Hemacue® in the out-patient clinic. Results Changes in blood glucose values from fasting were the lowest after 90 and 120 min (P < 0.01) when the dual wave was administered. When the dual or square-wave methods of insulin administration were used, subjects had significantly lower glucose levels after 4 h in comparison with when the single or double boluses were used (P = 0.04). Conclusions We conclude that the dual wave provided the most effective method of insulin administration for this meal. The dual- and square-wave therapies resulted in lower glucose levels 4 h after the meal in comparison with the single and double-bolus treatments.
- Subjects
PEOPLE with diabetes; INSULIN therapy; BLOOD sugar monitoring
- Publication
Diabetic Medicine, 2002, Vol 19, Issue 4, p317
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1046/j.1464-5491.2002.00685.x