We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mycobacterium tuberculosis PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation?
- Authors
Tundup, Smanla; Mohareer, Krishnaveni; Hasnain, Seyed E.
- Abstract
Necrotic cell death during TB infection is an important prerequisite for bacterial dissemination and virulence. The underlying mechanisms and the bacterial factors involved therein are not well understood. The Mycobacterium tuberculosis (M. tuberculosis) co‐operonic PE25/PPE41 protein complex, similar to ESAT‐6/CFP‐10, belonging to the PE/PPE and ESAT‐6 families of genes has co‐expanded and co‐evolved in the genomes of pathogenic mycobacteria. We report a novel role of this highly immunogenic PE25/PPE41 protein complex in inducing necrosis, but not apoptosis, in macrophages. We propose that these protein complexes of M. tuberculosis, secreted by similar/unique transport system (Type VII), have an important role in M. tuberculosis virulence and disease reactivation.
- Subjects
MYCOBACTERIUM tuberculosis; CELL death; MICROBIAL virulence; MYCOBACTERIA; MACROPHAGES
- Publication
FEBS Open Bio, 2014, Vol 4, Issue 1, p822
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1016/j.fob.2014.09.001