We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bone mineral density and fractures in institutionalised children with epilepsy and intellectual disability.
- Authors
Berkvens, J. J. L.; Mergler, S.; Beerhorst, K.; Verschuure, P.; Tan, I. Y.; Majoie, H. J. M.; van den Bergh, J. P. W.
- Abstract
Background: Long‐term use of antiseizure drugs is associated with a low bone mineral density (BMD) and an increased fracture risk. The literature regarding institutionalised children on chronic antiseizure drugs is limited. Therefore, the aim of this cross‐sectional study is to evaluate the prevalence of low BMD and the history of fractures in institutionalised children with epilepsy and intellectual disability (ID). Methods: A dual‐energy X‐ray absorptiometry of lumbar spine (L1–L4) and hip was performed in 24 children, residing in a long‐stay care facility in the Netherlands. Additionally, serum concentrations of albumin, calcium and 25‐hydroxyvitamin D were determined. Data on fractures were retrospectively extracted from the medical files. Results: Ages of the children (14 male and 10 female) ranged from 5 to 17 years with a mean age of 13.0 (±3.2). The criteria of the International Society for Clinical Densitometry (ISCD) were used for classification of bone mineral disorders. Eight (33.3%) children had a normal BMD (Z‐score > − 2.0). Of the 16 children with a low BMD (Z‐score ≤ − 2.0), three were diagnosed as osteoporotic, based on their fracture history. Ten children (41.7%) were reported to have at least one fracture in their medical history. Serum concentrations of albumin‐corrected calcium (2.28–2.50 mmol/L) and (supplemented) vitamin D (16–137 nmol/L) were within the normal range. Conclusions: This study demonstrated that 67% of institutionalised children with epilepsy and ID had low BMD and 42% had a history of at least one fracture, despite supplementation of calcium and vitamin D in accordance with the Dutch guidelines.
- Subjects
NETHERLANDS; ALBUMINS; PHOTON absorptiometry; EPILEPSY; CROSS-sectional method; RETROSPECTIVE studies; BONE fractures in children; VITAMIN D; DISEASE prevalence; DESCRIPTIVE statistics; BONE density; PEOPLE with intellectual disabilities; CALCIUM; INSTITUTIONAL care of children
- Publication
Journal of Intellectual Disability Research, 2021, Vol 65, Issue 11, p962
- ISSN
0964-2633
- Publication type
Article
- DOI
10.1111/jir.12880