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- Title
Juvenile generalized pustular psoriasis with IL36RN mutation treated with short-term infliximab.
- Authors
Pan, Junwei; Qiu, Li; Xiao, Ting; Chen, Hong‐Duo
- Abstract
ABSTRACT A 8-year-old Chinese boy with generalized pustular psoriasis (GPP) refractory to cyclosporine and methylprednisolone was treated successfully with two infusions of infliximab 3.3 mg/kg. He remained in remission for 21 months. Direct sequencing of IL36RN gene showed a homozygous mutation, c.115 + 6T>C. Juvenile GPP is a rare severe form of psoriasis occasionally associated with life-threatening complications. Like acitretin, cyclosporine and methotrexate, infliximab has been reported to be effective for juvenile GPP in case reports. However, there is a lack of data in the optimal treatment course of infliximab for juvenile GPP. Prolonged administration of these medications may cause toxic or fatal complications. We suggest that short-term infliximab regimen should be recommended as a choice for acute juvenile GPP refractory to traditional systemic therapies. WBC count and CRP are sensitive parameters to reflect the disease activity and evaluate the effectiveness of treatment. Monitoring CD4 T lymphocyte count, preventing and correcting CD4 lymphocytopenia are important in the treatment course of juvenile GPP.
- Subjects
INFLIXIMAB; PSORIASIS; METHYLPREDNISOLONE; CYCLOSPORINE; GENETIC mutation; PATIENTS; THERAPEUTICS
- Publication
Dermatologic Therapy, 2016, Vol 29, Issue 3, p164
- ISSN
1396-0296
- Publication type
Article
- DOI
10.1111/dth.12325