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- Title
Treatment of dermatitis herpetiformis and linear IgA bullous dermatosis.
- Authors
Herron, Mark; Zone, John
- Abstract
Dermatitis herpetiformis (DH) and linear IgA bullous dermatosis (LABD) are IgA-mediated autoimmune bullous diseases. They share an identical histopathology, but are differentiated on the basis of the pattern of IgA deposition on direct immunofluorescence. While DH responds to a gluten-free diet, LABD rarely responds to gluten restriction. In the management of DH, adhering to a gluten-free diet promotes healing of small intestine villus atrophy, resolution of cutaneous disease, and lowers the risk of lymphoma. Dapsone is palliative but not curative in the treatment of DH and LABD. Patients taking systemic dapsone or sulfa-based medication for the treatment of DH or LABD should have a reasonable knowledge of the inherent side effects.
- Subjects
DERMATITIS herpetiformis; IMMUNOFLUORESCENCE; GLUTEN; DAPSONE
- Publication
Dermatologic Therapy, 2002, Vol 15, Issue 4, p374
- ISSN
1396-0296
- Publication type
Article
- DOI
10.1046/j.1529-8019.2002.01547.x