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- Title
Circadian Behaviors of Oral and Skin Fibroblasts.
- Authors
Ngo, John; Hodaka Sasaki; Ichiro Nishimura
- Abstract
One of the key factors in oral and skin wound healing is fibroblast behaviors. This study reports fibroblasts derived from mouse palatal mucosa and dorsal skin. Oral fibroblasts exhibited robust expression of core clock genes as compared to skin fibroblasts and a clear circadian pattern in the cell migration and floating collagen gel contraction in vitro. Our study suggests that oral wound healing involving fibroblast repopulation and contraction may follow a diurnal cycle.
- Subjects
SKIN wound treatment; CIRCADIAN rhythms; FIBROBLASTS; CLOCK genes; CELL migration
- Publication
Journal of the California Dental Association, 2019, Vol 47, Issue 12, p801
- ISSN
1043-2256
- Publication type
Article
- DOI
10.1080/19424396.2019.12220865