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- Title
Farklı dozlarda ardıç yağının sıçan karaciğerinde antioksidan enzimler üzerine etkisi.
- Authors
Doğuç, Duygu Kumbul; Gürbüz, Nilgün; Aylak, Firdevs; Şavik, Emin; Gültekin, Fatih
- Abstract
Objective: Oil of Juniperus Communis Lynn (JCL) which is extracted from JCL leaves is a natural product. In the present study we investigated the effects of JCL oil on oxidative and anti-oxidative systems in liver tissue of hypercholesterolemic rats which were administered JCL oil to lower their cholesterol levels. Material-Method: Thirty-five, adult male Wistar albino rats were included and divided into 5 groups as control group (GI) (fed with normal pellet chow), the cholesterol (GII) group (fed with pellet chow containing 2% of cholesterol), the 3rd, 4th and 5th groups (fed with 50, 100, 200mg/kg JCL oil, respectively in addition to the 2% cholesterol-containing pellet chow). Following the 30 days administration period, rats were sacrified, liver tissues were taken. Oxidative (MDA) product and anti-oxidative (KAT, SOD, GSH-Px) enzymes were detected. Results: MDA levels of the groups that were fed with cholesterol were significantly increased compared with control group (p<0.01). The dose of 200mg/kg JCL (GV) did not lower, even increased the MDA levels compared to GII, in addition CAT and SOD activities in GV were significantly decreased compared to GI (p<0.01). Discussion: JCL oil provided antioxidant effect with the dose 50mg/kg but this effect did not prolong with higher doses in fact with the dose 200 mg/kg oxidative stress was increased. In conclusion it can be said that JCL oil may lead to different effects in a tissue-specific and dose-dependent manner.
- Subjects
JUNIPERUS communis; ANTIOXIDANTS; HYPERCHOLESTEREMIA; LABORATORY rats; CHOLESTEROL
- Publication
SDU Journal of Health Science Institute / SDÜ Saglik Bilimleri Enstitüsü Dergisi, 2012, Vol 3, Issue 2, p77
- ISSN
2146-247X
- Publication type
Article