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- Title
Akut Koroner Sendrom ile Gelen Hastalarda Çok Damar Hastalığı ile Monosit/HDL-C Oranı Arasındaki İlişki.
- Authors
TOPRAK, Kenan
- Abstract
Background: Acute coronary syndromes are among the most common causes of death worldwide. Inflammation has an important place in the etiology and pathogenesis of ACS (acute coronary syndrome). To date, many different parameters have been used to assess inflammation. Monocyte HDL ratio (MHR) is a new marker of inflammation that has come into use in recent years. The aim of our study is to determine the clinical significance of MHR in patients presenting with ACS. Materials and Methods: In this retrospective study, 195 patients who applied to our clinic with the diagnosis of acute coronary syndrome and underwent coronary angiography were included. Routine hematological and biochemical parameters of all patients were analyzed retrospectively. MHR was obtained by dividing the number of monocytes by HDL cholesterol. The patients were divided into 3 groups according to their MHR tertiles. All 3 groups were compared for angiographic features and MHR. Results: There was no significant difference between the 3 groups in terms of baseline demographic characteristics. However, it was determined that the frequency of 3-vessel disease increased gradually as MHR increased. (12%, 33%, 52%, respectively, p<0.001). In the correlation analysis, age (r= 0.326, p<0.001) and MHR (r=0.347, p<0.001) were positively correlated with the number of vessels with critical stenosis. In the multivariate logistic regression analysis, age (hazard ratio: 1.052; 95% confidence interval: 1.020 - 1.085; p = 0.001), MHR (hazard ratio: 1.075, 95% confidence interval: 1.192 - 5.087; p <0.001) and diabetes mellitus (hazard ratio: 2.462 ; 95% confidence interval: 1.192 -- 5.087; p = 0.015 ) were identified as independent predictors of multivessel disease. Taking the MHR cut-off value ≥ 19.1 predicted multivessel disease in patients with acute coronary syndrome, with a sensitivity of 71.9% and a specificity of 61.8%. Conclusions: MHR is a new marker of inflammation. In our study, we found that MHR independently predicted multivessel disease in patients presenting with ACS.
- Subjects
HDL cholesterol; CONFIDENCE intervals; MULTIVARIATE analysis; ACUTE coronary syndrome; RETROSPECTIVE studies; DESCRIPTIVE statistics; DATA analysis software; LOGISTIC regression analysis; MONOCYTES
- Publication
Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi, 2022, Vol 19, Issue 1, p98
- ISSN
1304-9623
- Publication type
Article
- DOI
10.35440/hutfd.1067425