We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Role of the AT-Rich Interaction Domain 1A Gene (ARID1A) in Human Carcinogenesis.
- Authors
Li, Jing Jing; Lee, Cheok Soon
- Abstract
The switch/sucrose non-fermentable (SWI/SNF) (SWI/SNF) complex uses energy from ATP hydrolysis to mobilise nucleosomes on chromatin. Components of SWI/SNF are mutated in 20% of all human cancers, of which mutations in AT-rich binding domain protein 1A (ARID1A) are the most common. ARID1A is mutated in nearly half of ovarian clear cell carcinoma and around one-third of endometrial and ovarian carcinomas of the endometrioid type. This review will examine in detail the molecular functions of ARID1A, including its role in cell cycle control, enhancer regulation, and the prevention of telomerase activity. ARID1A has key roles in the maintenance of genomic integrity, including DNA double-stranded break repair, DNA decatenation, integrity of the cohesin complex, and reduction in replication stress, and is also involved in mismatch repair. The role of ARID1A loss in the pathogenesis of some of the most common human cancers is discussed, with a particular emphasis on gynaecological cancers. Finally, several promising synthetic lethal strategies, which exploit the specific vulnerabilities of ARID1A-deficient cancer cells, are briefly mentioned.
- Subjects
DOUBLE-strand DNA breaks; HUMAN carcinogenesis; CHROMATIN-remodeling complexes; CARRIER proteins; PROTEIN domains; GYNECOLOGIC cancer; CELL cycle
- Publication
Genes, 2024, Vol 15, Issue 1, p5
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes15010005