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- Title
Metastatic Splenic Angiosarcoma Presenting With Thrombocytopenia and Bone Marrow Fibrosis Mimicking Idiopathic Thrombocytopenic Purpura and Primary Myelofibrosis: A Diagnostic Challenge.
- Authors
Hu, Shimin; Bueso-Ramos, Carlos E.; Verstovsek, Srdan; Miranda, Roberto N.; Cameron Yin, C.; McDonnell, Timothy; Jeffrey Medeiros, L.; Lin, Pei
- Abstract
The diagnosis of bone marrow metastasis of rare types of cancer can be very challenging in the absence of knowledge of the primary neoplasm. Consequently, the bone marrow changes associated with metastasis, such as fibrosis and cytopenia, can be easily attributed to a primary hematopoietic process. We report a case of an 83-year-old patient initially presenting with symptoms related to cytopenia. Multiple diagnoses, including refractory idiopathic thrombocytopenic purpura and primary myelofibrosis, were rendered, and a variety of treatment protocols were tried at 3 different institutions before a final diagnosis of metastatic angiosarcoma of spleen was established 4 years after the patient's initial presentation. To the best of our knowledge, this is the first report that a bone marrow workup can lead to a diagnosis of primary splenic angiosarcoma.
- Publication
Clinical Lymphoma, Myeloma & Leukemia, 2013, Vol 13, Issue 5, p629
- ISSN
2152-2650
- Publication type
Article
- DOI
10.1016/j.clml.2012.12.013