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- Title
The role of C-MYC expression in low-grade follicular lymphoma with high proliferative index: A potential marker of clinically aggressive disease.
- Authors
Borowy-Borowski, Paul; Ross, Catherine; Sur, Monalisa
- Abstract
Follicular lymphoma (FL) is a common non-Hodgkin lymphoma of B-cell origin that is graded using WHO criteria into low grade (grades 1 and 2), and high grade (grades 3A and 3B). The proliferation index (PI) is measured by the proportion of cells staining positive for the immunohistochemical marker Ki-67 and has been shown to correlate with histologic grade. Low grade follicular lymphoma (LGFL) usually has a PI of <20%; high grade lesions have higher PI. Additionally, a rare subset of the LGFL's have been shown to have high PI (PI of >20%). It has been demonstrated that these LGFL's with high PI (LGHPI) follow a more aggressive course than their low PI counterparts with significantly shorter progression free and overall survival. The role of the C-MYC translocation, t(8;14), is well documented in high grade B-cell lymphomas; However, its expression and effect on the clinical outcomes in LGFL's has not been extensively studied apart from small case reports/series. Our study assessed the status of C-MYC in a LH-HPI cohort with fluorescence in-situ hybridization using a break-apart probe on samples from formalin-fixed paraffin embedded tissue. Three of the 46 cases tested were positive for the C-MYC translocation, similar to the occurrence in conventional diffuse large B-cell lymphoma. Follow-up showed that 2 of the 3 cases positive for C-MYC had aggressive behavior. This study adds to the emerging literature on this subset of FL and the utility of possible biomarkers in assessing clinical outcomes.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, p46
- ISSN
1918-915X
- Publication type
Article