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- Title
Central Nervous System Metastases from Gynecologic Tumours: A Clinicopathologic Study of 8 Cases.
- Authors
Qi Zhang; Lee Cyn Ang
- Abstract
Objective: Central nervous system (CNS) metastasis from gynecological malignancies (including epithelial ovarian cancer; endometrial cancer and cervical cancer) is rare. With better treatments for these patients and longer survival, more such cases have been reported. We are reporting 8 cases from the London Health Sciences Centre (LHSC), Ontario. Method: We have identified 8 cases of gynecological cancer with CNS metastasis, from the surgical pathology files of the Pathology Department at LHSC (January 2005 to June 2015). Pathological features (histological type, grade, tumour stage) and clinical data (patient demographic data, risk factors, treatments and overall survival) were analyzed. Results: Of the 8 gynecological cancers, 5 cases are primary endometrial carcinoma, including 3 endometrioid carcinoma, 1 mixed clear cell and endometrioid carcinoma, and 1 carcinosarcoma, all of which showing high grade histology. Two primary ovarian tumours are both high grade serous carcinoma. Of interests, one of the ovarian cancer patients had concurrent invasive mammary carcinoma, while the second patient had germ line BRCA1 mutation. The last case is a cervical invasive squamous cell carcinoma. The location of the CNS metastasis includes parietal lobe, frontal lobe, occipital lobe, cerebellum and spinal cord. All patients are treated with surgery and adjuvant chemoradiation therapy. Two patients are still alive by January 2016, with the longest survival time being 6 years from the primary diagnosis. Conclusions: Although rare, pathologists and clinicians should be aware of CNS metastasis by gynecological malignancy. Patients with BRCA1 mutation and/or concurrent breast cancer may have increased risk.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, p38
- ISSN
1918-915X
- Publication type
Article