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- Title
Case of Morvan syndrome with anti-Ma2/Ta antibodies.
- Authors
Nishioka, Kenya; Hoshino, Yasunobu; Kanai, Kauzuaki; Ueno, Shinichi; Nakazato, Tomoko; Takanashi, Masashi; Tanaka, Ryota; Yokoyama, Kazumasa; Arimura, Kimiyoshi; Kuwabara, Satoshi; Hattori, Nobutaka
- Abstract
The anti-paraneoplastic (Ma2/Ta) antibody is related to testicular, lung and ovarian cancers, and might cause paraneoplastic neurological disorders. We present a 25-year-old woman presenting various neurological symptoms of myokymia, chronic widespread pain, tremor, excessive daytime sleepiness, impaired eye of movements, and seizures and autonomic symptoms related to anti-Ma2/Ta antibodies. Needle electromyography showed spontaneous multiplet and myokymic discharges in the left vestus lateralis. Thus, we diagnosed her as Morvan syndrome. After initiation of steroids, plasma exchange and dantrolene, her symptoms partially improved with decreasing intensity of the antigen of anti-Ma2/Ta antibodies, from moderate strong to borderline. The present case expands the clinical spectrum of anti-Ma2/Ta antibodies-related disorders to include the existence of neuroimmune activation and Morvan syndrome.
- Subjects
IMMUNOGLOBULINS; NEUROLOGICAL disorders; MYOTONIA; PLASMA exchange (Therapeutics); DANTROLENE
- Publication
Clinical & Experimental Neuroimmunology, 2016, Vol 7, Issue 4, p369
- ISSN
1759-1961
- Publication type
Article
- DOI
10.1111/cen3.12325